Strain Information

Name JH3553   View On Wormbase
Species C. elegans
Genotypemeg-3(ax4503[del(1-544)::OLLAS]) meg-4(ax4504) X.
DescriptionDescription: 20% maternal effect sterility on average, RNAi insensitivity, MEG-3 does not form cytoplasmic gradient. meg-3(ax4503) is an in-frame deletion in the endogenous meg-3 locus removing amino acids (1-544); MEG-3 does not form a cytoplasmic gradient but does still form granules in early embryos and co-localizes with PGL-3. References: Smith, J. et al. Elife. 2016 Dec 3;5:e21337. doi: 10.7554/eLife.21337. PMID: 27914198 Schmidt H, bioRxiv 2020.10.15.340570 (2020) doi:10.1101/2020.10.15.340570.
Made byHelen Schmidt
Laboratory JH
Reference Schmidt, H., Putnam, A., Rasoloson, D. & Seydoux, G. Coordination of RNA and protein condensation by the P granule protein MEG-3. bioRxiv 2020.10.15.340570 (2020) doi:10.1101/2020.10.15.340570.
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