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JH3553 C. elegans meg-3(ax4503[del(545-862)::OLLAS]) meg-4(ax4504) X. Show Description
20% maternal effect sterility on average, RNAi insensitivity, MEG-3 does not form cytoplasmic gradient. meg-3(ax4503) is an-frame deletion in the endogenous meg-3 locus removing amino acids 545-862; MEG-3 does not form a cytoplasmic gradient but does still form granules in the early embryos and co-localizes with PGL-3 . References: Smith, J. et al. Elife. 2016 Dec 3;5:e21337. doi: 10.7554/eLife.21337. PMID: 27914198 Schmidt H, bioRxiv 2020.10.15.340570 (2020) doi:10.1101/2020.10.15.340570.