Strain Information

Name ZX2604   View On Wormbase
Species C. elegans
Genotypesng-1(ok234) X; zxIs127.
DescriptionzxIs127 [sng-1p::SNG-1::CRY2olig(535) + myo-2p::mCherry]. Strain should be kept in the dark; it is very light-sensitive. Pan-neuronal expression of a truncated variant of Arabidopsis thaliana Cryptochrome-2 fused to synaptogyrin. If illuminated with blue light, synaptic vesicles cluster, resulting in inhibition of synaptic transmission. Synaptic transmission is restored within 15 minutes in the absence of light (ca. 6.5min time constant), resulting in normal wild type behavior afterwards. Reference: Vettkotter D, et al. Nat Commun 13, 7827 (2022). PMID: 36535932
MutagenNo mutagen
Made byDennis Vettkötter
Laboratory ZX
Reference Vettkotter, D., Schneider, M., Goulden, B.D. et al. Rapid and reversible optogenetic silencing of synaptic transmission by clustering of synaptic vesicles. Nat Commun 13, 7827 (2022).
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