Strain Information
| Name | WOP159 View On Wormbase |
|---|---|
| Species | C.elegans |
| Genotype | ahcy-1(syb784 *syb646[ahcy-1(Y145C)::GFP]) I. |
| Description | Engineered Y145C substitution mutation in endogenously GFP-tagged ahcy-1 locus. ahcy-1(Y145C) mutation mimics the pathogenic human mutation AHCY Y143C. ahcy-1(Y145C) mutants have a prolonged lifespan and are larger than control animals. ahcy-1(Y145C) mutants are fertile and produce a brood of laid and hatched eggs similar to control animals. ahcy-1(Y145C) mutants show a slight increase in SAH and a decrease in SAM levels, leading to an increased SAH to SAM ratio. See WOP122 for control strain. Derived by out-crossing parental strain PHX784 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822. |
| Mutagen | |
| Outcrossed | x2 |
| Made by | SunyBiotech |
| Laboratory | WOP |
| Reference | Thapa, P., Olek, K., Kowalska, A. et al. SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model. npj Aging 9, 27 (2023). https://doi.org/10.1038/s41514-023-00125-1 |
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