Strain Information

Name WOP159   View On Wormbase
Species C.elegans
Genotypeahcy‐1(syb784 *syb646[ahcy‐1(Y145C)::GFP]) I.
DescriptionEngineered Y145C substitution mutation in endogenously GFP-tagged ahcy-1 locus. ahcy-1(Y145C) mutation mimics the pathogenic human mutation AHCY Y143C. ahcy-1(Y145C) mutants have a prolonged lifespan and are larger than control animals. ahcy-1(Y145C) mutants are fertile and produce a brood of laid and hatched eggs similar to control animals. ahcy-1(Y145C) mutants show a slight increase in SAH and a decrease in SAM levels, leading to an increased SAH to SAM ratio. See WOP122 for control strain. Derived by out-crossing parental strain PHX784 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822.
MutagenNo mutagen
Outcrossedx2
Made bySunyBiotech
Laboratory WOP
Reference Thapa, P., Olek, K., Kowalska, A. et al. SAM, SAH and C. elegans longevity: insights from a partial AHCY deficiency model. npj Aging 9, 27 (2023). https://doi.org/10.1038/s41514-023-00125-1
Sign in or register an account if you want to order this strain.