Laboratory Information

NameWOP View on WormBase
Allele designationjjp
HeadWojciech Pokrzywa
InstitutionInternational Institute of Molecular and Cell Biology in Warsaw
Address Laboratory of Protein Metabolism
4 Ks. Trojdena St.
Warsaw 02-109
Poland
Gene classes

Strains contributed by this laboratory

Strain Genotype Species Description
WOP122 ahcy‐1(syb646[ahcy‐1::GFP]) I. C.elegans GFP tag inserted at C-terminus of endogenous ahcy-1 locus. Derived by out-crossing parental strain PHX646 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822.
WOP159 ahcy‐1(syb784 *syb646[ahcy‐1(Y145C)::GFP]) I. C.elegans Engineered Y145C substitution mutation in endogenously GFP-tagged ahcy-1 locus. ahcy-1(Y145C) mutation mimics the pathogenic human mutation AHCY Y143C. ahcy-1(Y145C) mutants have a prolonged lifespan and are larger than control animals. ahcy-1(Y145C) mutants are fertile and produce a brood of laid and hatched eggs similar to control animals. ahcy-1(Y145C) mutants show a slight increase in SAH and a decrease in SAM levels, leading to an increased SAH to SAM ratio. See WOP122 for control strain. Derived by out-crossing parental strain PHX784 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822.
This laboratory hasn't submitted any alleles to the CGC.