Laboratory Information
| Name | WOP View on WormBase |
|---|---|
| Allele designation | jjp |
| Head | Wojciech Pokrzywa |
| Institution | International Institute of Molecular and Cell Biology in Warsaw |
| Address | Laboratory of Protein Metabolism 4 Ks. Trojdena St. Warsaw 02-109 Poland |
| Gene classes |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| WOP122 | ahcy-1(syb646[ahcy-1::GFP]) I. | C.elegans | GFP tag inserted at C-terminus of endogenous ahcy-1 locus. Derived by out-crossing parental strain PHX646 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822. |
| WOP159 | ahcy-1(syb784 *syb646[ahcy-1(Y145C)::GFP]) I. | C.elegans | Engineered Y145C substitution mutation in endogenously GFP-tagged ahcy-1 locus. ahcy-1(Y145C) mutation mimics the pathogenic human mutation AHCY Y143C. ahcy-1(Y145C) mutants have a prolonged lifespan and are larger than control animals. ahcy-1(Y145C) mutants are fertile and produce a brood of laid and hatched eggs similar to control animals. ahcy-1(Y145C) mutants show a slight increase in SAH and a decrease in SAM levels, leading to an increased SAH to SAM ratio. See WOP122 for control strain. Derived by out-crossing parental strain PHX784 two times to N2. Reference: Thapa P, et al. NPJ Aging. 2023 Dec 5;9(1):27. doi: 10.1038/s41514-023-00125-1. PMID: 38052822. |
This laboratory hasn't submitted any alleles to the CGC.