Strain Information

Name BJH728   View On Wormbase
Species C. elegans
Genotypeunc-26(pek288[R216Q]) IV.
Descriptionunc-26(pek288) is a CRISPR-engineered R216Q substitution in unc-26/synaptojanin 1 associated with early-onset Parkinsonism (EOP) (Quadri et al., 2013; Krebs et al., 2013). This allele shows abnormal focal accumulation of ATG-9 in presynaptic nerve terminals, defects in activity-induced synaptic autophagy, and defects in sustained neurotransmission and locomotory behaviors in aging animals. Reference: Yang S, et al. Neuron. 2022 Mar 2;110(5):824-840.e10. PMID: 35065714
MutagenNo mutagen
Made bySisi Yang
Laboratory DCR
Reference Yang, S., Park, D., Manning, L., Hill, S. E., Cao, M., Xuan, Z., ... & Colón-Ramos, D. A. (2022). Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Neuron, 110(5), 824-840.
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