Strain Information
| Name | BJH728 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | unc-26(pek288[R216Q]) IV. |
| Description | unc-26(pek288) is a CRISPR-engineered R216Q substitution in unc-26/synaptojanin 1 associated with early-onset Parkinsonism (EOP) (Quadri et al., 2013; Krebs et al., 2013). This allele shows abnormal focal accumulation of ATG-9 in presynaptic nerve terminals, defects in activity-induced synaptic autophagy, and defects in sustained neurotransmission and locomotory behaviors in aging animals. Reference: Yang S, et al. Neuron. 2022 Mar 2;110(5):824-840.e10. PMID: 35065714 |
| Mutagen | No mutagen |
| Outcrossed | x1 |
| Made by | Sisi Yang |
| Laboratory | DCR |
| Reference | Yang, S., Park, D., Manning, L., Hill, S. E., Cao, M., Xuan, Z., ... & Colón-Ramos, D. A. (2022). Presynaptic autophagy is coupled to the synaptic vesicle cycle via ATG-9. Neuron, 110(5), 824-840. |
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