Strain Information
| Name | AMP100 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | ieSi57 II; rpb-2(cer135[rpb-2::GFP(delta)piRNA::AID::3xFLAG]) III. |
| Description | ieSi57 [eft-3p::TIR1::mRuby::unc-54 3'UTR + Cbr-unc-119(+)] II. cer135 is a rpb-2::GFP(delta)piRNA::AID::3xFLAG tag inserted into the endogenous rpb-2 locus. This strain allows auxin-dependent disruption of RNA polymerase II with dose-dependent lifespan shortening. Reference: Oswal N, et al. PLoS Comput Biol. 2022 Sep 30;18(9):e1010415. PMID: 36178967. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x1 |
| Made by | J. Vicencio, N. Oswal, N.Stroustrup & J. Ceron |
| Laboratory | AMP |
| Reference | PLoS Comput Biol. 2022 Sep 30;18(9):e1010415. doi: 10.1371/journal.pcbi.1010415. eCollection 2022 Sep. A hierarchical process model links behavioral aging and lifespan in C. elegans Natasha Oswal, Olivier M F Martin, Sofia Stroustrup, Monika Anna Matusiak Bruckner, Nicholas Stroustrup PMID: 36178967 PMCID: PMC9524676 DOI: 10.1371/journal.pcbi.1010415 |
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