Strain Information

Name ZM10113   View On Wormbase
Species C. elegans
Genotypetwk-40(bln282[twk-40::TagRFP::ZF]) III; hpIs727.
DescriptionhpIs727 [rig-3p::zif-1::sl2::RFP + ttx-3p::GFP]. twk-40(bln282) is a CRISPR generated tagged allele of endogenous twk-40 locus inserting TagRFP and a ZIF-1 directed degron to the endogenous TWK-40, allowing visualization of endogenous protein expression and localization as well as targeted degradation. The presence of hpIs727 in the background leads to specific degradation of TWK-40 from AVA, causing loopy forward and reversal movement compared to twk-40(bln282) alone.
MutagenNo mutagen
Made byJun Meng
Laboratory ZM
Reference A tonically active neuron continuously drives mutually exclusive motor states at different timescales. Meng et al., 2023. Submitted.
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