Strain Information
| Name | ZG31 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | hif-1(ia4) V. |
| Description | Healthy and fertile in standard lab conditions, but unable to adapt to 1% oxygen. When hif-1(+) animals are incubated in1% oxygen, >94% will complete embryogenesis and larval development. In contrast, hif-1(ia4) mutants exhibit 66% embryonic lethality and 9% larval lethality in 1% oxygen. The requirement of hif-1 is alleviated if the oxygen level is increased to 2%. The ia4 mutation is a 1231 bp deletion of the second, third, and fourth exons, which encode much of the helix-loop-helix and PAS domains. Analysis of ESTs suggests that there are at least 4 alternatively spliced hif-1 transcripts. The ia4 deletion introduces a frameshift and a premature stop in the three longest forms. |
| Mutagen | EMS |
| Outcrossed | x9 |
| Made by | Jiang/Powell-Coffman |
| Laboratory | ZG |
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