Strain Information
Name | YA1039 View On Wormbase |
---|---|
Species | C. elegans |
Genotype | mrt-1(yp2) I. |
Description | yp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63. |
Mutagen | |
Outcrossed | x7 |
Made by | Shawn Ahmed |
Laboratory | YA |
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