Strain Information

Name YA1039   View On Wormbase
Species C. elegans
Genotypemrt-1(yp2) I.
Descriptionyp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63.
Made byShawn Ahmed
Laboratory YA
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