Laboratory Information
| Name | YA View on WormBase |
|---|---|
| Allele designation | yp |
| Head | Shawn Ahmed |
| Institution | University of North Carolina, Chapel Hill, NC |
| Address | Coker Hall University of North Carolina Department of Genetics Chapel Hill 27599-3280 United States |
| Website | http://www.bio.unc.edu/ahmed/lab/ |
| Gene classes | est pot |
Strains contributed by this laboratory
| Strain | Genotype | Species | Description |
|---|---|---|---|
| YA1039 | mrt-1(yp2) I. | C. elegans | yp2 mutation perturbs the MRT-1 DNA-binding domain. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63. |
| YA1059 | trt-1(ok410) I. | C. elegans | Becomes very sick if starved for extended periods of time or if frozen and thawed repeatedly. Primer sequences provided by the C. elegans Reverse Genetics Core Facility for ok410 are: Outer Left Sequence: AAGACTGTCAGCTGGTGGGT. Outer Right Sequence: TTAGCCTTACATTGCCGCTT. Inner Left Sequence: TCATGCGCAACATCTAAAGC. Inner Right Sequence: CGAATAAAGCAATTTCCCGA. Inner primer WT PCR product: 2825. |
| YA1116 | mrt-1(tm1354) I. | C. elegans | Null allele. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63. |
| YA893 | mrt-1(e2662) I. | C. elegans | Null allele. Mortal germline. Progressive telomere shortening due to telomerase dysfunction. Hypersensitive to DNA interstrand crosslinking agents. This strain will become sterile after propagating 10-20 generations. mrt-1 mutants can be rejuvenated by outcrossing. Reference: Meier B, et al. EMBO J. 2009 Nov 18;28(22):3549-63. [NOTE: allele is incorrectly described as e2661 in this publication.] |
Alleles contributed by this laboratory
| Allele | Type | DNA Change | Protein Change |
|---|---|---|---|
| yp2 | Allele | substitution |