Strain Information
| Name | WRM92 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | oma-1(spr24[*ne5035]) IV; oma-2(ne5034[AID*::oma-2] neSi101 V. |
| Description | neSi101 [sun-1p::TIR1::mRuby::eft-3 3'UTR + Cbr-unc-119(+)] IV. GFP reporter inserted into C-terminus of endogenous oma-1 locus. A triple arginine motif upstream of the oma-1 tandem zinc finger domain is mutated to three alanines. AID* degron tag (IAA17) inserted into the endogenous oma-2 locus. When OMA-2 is present, this mutant does not appear to have obvious phenotypes. Auxin-inducible depletion of OMA-2 causes embryonic lethality: animals lay low numbers of nonviable embryos that are often polynucleated and have weak chitin shells. Reference: Ertekin A, et al. bioRxiv. 2025 May 12:2025.05.09.653132. doi: 10.1101/2025.05.09.653132. PMiD: 40463014. |
| Mutagen | No mutagen |
| Outcrossed | x3 |
| Made by | Sharon Noronha |
| Laboratory | WRM |
| Reference | Ertekin, A., Noronha, S.T., Darko, C., Massi, F., & Ryder S.P. (2025). A conserved triple arginine motif in OMA-1 is required for RNA-binding activity and embryo viability. RNA. Advance online publication. https://doi.org/10.1261/rna.080611.125 |
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