Strain Information

Name WRM31   View On Wormbase
Species C elegans
GenotypesprDf1 V/nT1 [qIs51] (IV,V).
DescriptionPick GFP+ to maintain. sprDf1 is a ~0.25 Mb microdeletion allele on the left arm of chromosome V that removes 32 adjacent protein-coding genes, including mex-5. Heterozygous animals (GFP+) are fertile, but sometimes die by bursting, will have polynucleated embryos, and form uterine tumors ~6 days after hatching. sprDf1 homozygotes (GFP-) have maternal effect lethality, are small, sterile, form large uterine tumors that consist of poly nucleated embryos, have squashed vulvas, are uncoordinated, and die by bursting within eight days of hatching. nT1 homozygotes are inviable (dead eggs). Reference: Antkowiak KR, et al. G3 (Bethesda). 2023 Nov 13:jkad258. doi: 10.1093/g3journal/jkad258. PMID: 37956108.
Made byKatianna R Antkowiak
Laboratory WRM
Reference Katianna R Antkowiak, Peren Coskun, Sharon T Noronha, Davide Tavella, Francesca Massi, Sean P Ryder, A nematode model to evaluate microdeletion phenotype expression, G3 Genes|Genomes|Genetics, 2023;, jkad258,
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