Strain Information
| Name | WG300 View On Wormbase |
|---|---|
| Species | C.elegans |
| Genotype | rmIs190; hdEx2. |
| Description | rmIs190 [F25B3.3p::Q67::CFP]. hdEx2 [snb-1::ALKBH3(H257A)::BFP::tbb-2 3’UTR + rol-6(su1006)]. Pick Rollers to maintain. BFP fused to the C-terminus of catalytically inactive ALKBH3(H257A) mutant form of ALKBH3. Pan-neuronal CFP expression. Reference: Sun Y, et al. Nature. 2023 Nov;623(7987):580-587. doi: 10.1038/s41586-023-06701-5. PMID: 37938769. |
| Mutagen | No mutagen |
| Outcrossed | x5 |
| Made by | Hui Dai |
| Laboratory | 4010 |
| Reference | Sun, Y., Dai, H., Dai, X. et al. m1A in CAG repeat RNA binds to TDP-43 and induces neurodegeneration. Nature 623, 580–587 (2023). https://doi.org/10.1038/s41586-023-06701-5 |
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