Strain Information
Name | UP3542 View On Wormbase |
---|---|
Species | C. elegans |
Genotype | lpr-3(cs231) X; csEx436. |
Description | csEx436 [lpr-3 (fosmid WRM619dE09) + myo-2p::mCherry]. Pick mCherry+ animals to maintain. cs231 is a Crispr/Cas9-induced null allele of lpr-3: a 13 nucleotide deletion in exon 1 results in frameshift. Homozygous mutants are embryonic lethal, but are rescued by csEx436 containing lpr-3(+) fosmid WRM619dE09. NOTE: lpr-3(cs231) should be considered the canonical allele as ok2351 also perturbs expression of adjacent gene lpr-6. Reference: Forman-Rubinsky R, Cohen JD and Sundaram MV. Genetics. 2017 Oct;207(2):625-642. |
Mutagen | Crispr/Cas9 |
Outcrossed | x2 |
Made by | Rachel Forman-Rubinsky |
Laboratory | UP |
Reference | Forman-Rubinsky, R., Cohen, J.D. and Sundaram, M.V. (2017). Lipocalins are required for apical extracellular matrix organization and remodeling in Caenorhabditis elegans. Genetics 207, 625-642. |
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