Strain Information

Name SZ304   View On Wormbase
Species C. elegans
Genotypeunc-73(e936) I; prp-8(az119) III.
Descriptionprp-8(az119) is a D1549N missense allele. az119 is a CRISPR-induced mutation mimicking a known suppressor of unc-73(e936). az119 suppresses unc-73(e936) uncoordination through activation of cryptic splicing that promotes full length UNC-73 production. Reference: Cartwright-Acar CH, et al. Nucleic Acids Res. 2022 Nov 11;50(20):11834-11857. doi: 10.1093/nar/gkac991. PMID: 36321655.
Made byAlan Zahler
Laboratory SZ
Reference Catiana H Cartwright-Acar and others, A forward genetic screen in C. elegans identifies conserved residues of spliceosomal proteins PRP8 and SNRNP200/BRR2 with a role in maintaining 5′ splice site identity, Nucleic Acids Research, Volume 50, Issue 20, 11 November 2022, Pages 11834–11857,
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