Strain Information

Name SZ197   View On Wormbase
Species C. elegans
Genotypeunc-73(e936) I; prp-8(az50) III.
Descriptionprp-8(az50) is a T524S missense allele that affects cryptic splicing (5'ss choice) of unc-73(e936) to allow more UNC-73 protein to be produced. PRP-8 is the largest protein in the spliceosome (essential) with a role in all stages of splicing. Reference: Mayerle M, et al. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2193-2199. doi: 10.1073/pnas.1819020116. PMID: 30674666.
Made byAlan Zahler
Laboratory SZ
Reference Mayerle M, Yitiz S, Soulette C, Rogel LE, Ramirez A, Ragle JM, et al. Prp8 impacts cryptic but not alter- native splicing frequency. Proc Natl Acad Sci U S A. 2019; 116: 2193–2199. pnas.1819020116 PMID: 30674666 DNA sequence of allele is found in supplemental material
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