Strain Information
| Name | SZ197 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | unc-73(e936) I; prp-8(az50) III. |
| Description | prp-8(az50) is a T524S missense allele that affects cryptic splicing (5'ss choice) of unc-73(e936) to allow more UNC-73 protein to be produced. PRP-8 is the largest protein in the spliceosome (essential) with a role in all stages of splicing. Reference: Mayerle M, et al. Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):2193-2199. doi: 10.1073/pnas.1819020116. PMID: 30674666. |
| Mutagen | CRIPSR/Cas9 |
| Outcrossed | x2 |
| Made by | Alan Zahler |
| Laboratory | SZ |
| Reference | Mayerle M, Yitiz S, Soulette C, Rogel LE, Ramirez A, Ragle JM, et al. Prp8 impacts cryptic but not alter- native splicing frequency. Proc Natl Acad Sci U S A. 2019; 116: 2193–2199. https://doi.org/10.1073/ pnas.1819020116 PMID: 30674666 DNA sequence of allele is found in supplemental material |
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