Strain Information
| Name | SBP67 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | spat-3(mgw14[R209Q]) X. |
| Description | Egl, with defects in HSN migration, and HSN and PVQ axon guidance. Crispr/Cas9 induced mutation in Ring1 domain with epigenetic effects on neurodevelopment. Amino acid substitution that likely disrupts interaction with a specific substrate, resulting in a phenotype comparable to a complete gene deletion. Reference: Pierce SB, et al. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1558-1563. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x1 |
| Made by | Sarah Pierce |
| Laboratory | SBP |
| Reference | De novo mutation in RING1 with epigenetic effects on neurodevelopment. Pierce SB, Stewart MD, Gulsuner S, Walsh T, Dhall A, McClellan JM, Klevit RE, King MC. Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):1558-1563. doi: 10.1073/pnas.1721290115. Epub 2018 Jan 31. PMID: 29386386 |
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