Strain Information
| Name | PHX8127 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | srm-1(syb8127[unc-25p(fragment)::SL1-aaaa::FLP D5::let-858 3’UTR]) IV. |
| Description | srm-1(syb8127[dpy-10 sgRNAsite::unc-25 fragment with tataa sites::dpy-10 sgRNAsite::SL1-aaaa::FLP D5::let-858 3’utr]) (IV:5015000). FLP D5 recombinase driver expressed from a fragment of the unc-25 promoter that expresses in RME neurons. Recombination was only modestly penetrant. Promoter construct contains dpy-10 sites allowing for a straightforward exchange of the promoter. Reference: Rossi L, et al. Curr Biol. 2025 Apr 20:S0960-9822(25)00355-0. doi: 10.1016/j.cub.2025.03.039. PMID: 40273913. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x0 |
| Made by | SunyBiotech / Henrik Bringmann |
| Laboratory | HBR |
| Reference | “The neuropeptide FLP-11 induces and self-inhibits sleep through the receptor DMSR-1 in Caenorhabiditis elegans” doi: 10.1016/j.cub.2025.03.039. |
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