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|Species|| C. elegans |
|Genotype||pink-1(ok3538) II; feIs5 X.|
|Description||feIs5 [sur-5p::luciferase::GFP + rol-6(su1006)] X. Rollers. Strain expresses firefly (Photinus pyralis) luciferase (lacking the peroxisome tagging signal) fused in-frame to GFP(S65C) in the pink-1(ok3538) mutant background. It is rendered bioluminescent when it ingests D-luciferin. This strain is for academic use only. This strain cannot be distributed to commercial organizations. This strain cannot be used for any commercial purpose or for work on human subjects. References: Lagido, C, et. al. (to be submitted to bioRxiv). Novel HTS platform for the identification of drugs active in the modulation of mitochondrial function in age-related diseases.|
|Made by||Cristina Lagido|
|Reference ||Lagido C 2018. In vivo luminescent ATP C. elegans sensor strains for drug discovery in age-related diseases – an update. EMBO workshop. C. elegans development, cell biology and gene expression. Barcelona, Spain, 13-17th
Lagido, Cristina., McLaggan, Debbie., & Glover, L. A.( 2015). An in vivo sensor of mitochondrial function in C. elegans for toxicity screening and repositioning of drugs presented in International Worm Meeting.
Lagido, C, et. al. (to be submitted to bioRxiv). Novel HTS platfo|