Strain Information
| Name | NJL3198 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | skn-1(nic952)/tmC25[unc-5(tmIs1241)] IV. |
| Description | Isoform-specific activation of SKN-1C. Heterozygotes are GFP+ and non-Unc. Segregates GFP+ non-Unc (heterozygotes), GFP+ Unc (tmC25 homozygotes), and GFP- non-Unc (skn-1 homozygotes). Eggs produced by skn-1(nic952) homozygotes do not hatch. Maintain by picking GFP+ non-Unc heterozygotes and checking for correct segregation of progeny. Reference: Jochim B, et al. PLoS Genet. 2025 Jul 7;21(7):e1011780. doi: 10.1371/journal.pgen.1011780. PMID: 40623109. |
| Mutagen | CRISPR-Cas9 |
| Outcrossed | x0 |
| Made by | Briar Jochim |
| Laboratory | NJL |
| Reference | Jochim B, Topalidou I, Lehrbach N (2025) Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2. PLoS Genet 21(7): e1011780. https://doi.org/10.1371/journal.pgen.1011780 |
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