Strain Information
| Name | MCJ180 View On Wormbase |
|---|---|
| Species | C elegans |
| Genotype | mir-35(cdb2 cdb72) II. |
| Description | cdb2 cdb72 is a mutation to the 3' end of the mature mir-35 creating a 3’ end containing nucleotides that are not present or rare among all mir-35 family members at a given position, while preserving overall GC content. This mir-35 mutant strongly impacts embryonic abundance of mir-35 but does not affect its decay at embryo to L1. Superficially wild-type. Reference: Donnelly BF, et al. (2022). Cell Reports. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x2 |
| Made by | Bridget Donnelly |
| Laboratory | MCJ |
| Reference | Donnelly, B.F., Yang, B., Grimme, A.L., Vieux, K.-F., Liu, C.-Y., Zhou, L., and McJunkin, K. (2022). The developmentally-timed decay of an essential microRNA family is seed sequence-dependent. BioRxiv 2021.11.19.469346. |
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