Strain Information

Name KAE112   View On Wormbase
Species C. elegans
DescriptionseaIs201 [myo-3p::human tau (0N4R;V337M)::unc-54 3'UTR + vha-6p::mCherry::unc-54 3'UTR]. Reduced crawling speed, reduced brood size, shortened lifespan, slow development, early paralysis. Human tau transgene is expressed in body wall muscles, producing strong phenotypes suitable for screening and is sensitive to knockdown by feeding RNAi. Generated in N2 background.
Made byJoshua Russell
Laboratory KAE
Reference The article describing this strain is currently under review at The Journal of Gerontology. I can update this once it is published.
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