Laboratory Information
Name | KAE View on WormBase |
---|---|
Allele designation | sea |
Head | Matt Kaeberlein |
Institution | University of Washington, Seattle, WA |
Address | 1959 NE Pacific St HSB Room D512 Box 357470 Seattle 98195 United States |
Website | www.kaeberleinlab.org |
Gene classes | tald impk |
Strains contributed by this laboratory
Strain | Genotype | Species | Description |
---|---|---|---|
KAE10 | seaSi40 I; unc-119(ed3) III. | C. elegans | seaSi40 [(pCFJ448) (eft-3p::fmo-2 + H2B::GFP) + Cbr-unc-119(+)] I. Higher level of FMO-2 over-expression compared to KAE9. Improved healthspan, stress resistance and longevity. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8. |
KAE112 | seaIs201. | C. elegans | seaIs201 [myo-3p::human tau (0N4R;V337M)::unc-54 3'UTR + vha-6p::mCherry::unc-54 3'UTR]. Reduced crawling speed, reduced brood size, shortened lifespan, slow development, early paralysis. Human tau transgene is expressed in body wall muscles, producing strong phenotypes suitable for screening and is sensitive to knockdown by feeding RNAi. Generated in N2 background. |
KAE12 | seaSi182 II; unc-119(ed3) III. | C. elegans | seaSi182 [(pCFJ150) (vha-6p::fmo-2 + H2B::GFP) + Cbr-unc-119(+)] II. Over-expression of FMO-2 in the intestine. Long-lived. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8. |
KAE28 | unc-119(ed3) III; seaEx13. | C. elegans | seaEx13 [fmo-2p::GFP + unc-119(+)]. Pick non-Unc to maintain. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8. |
KAE9 | seaSi39 I; unc-119(ed3) III. | C. elegans | seaSi39 [(pCFJ448) (eft-3p::fmo-2 + H2B::GFP) + Cbr-unc-119(+)] I. Lower level of FMO-2 over-expression compared to KAE10. Improved healthspan, stress resistance and longevity. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8. |
This laboratory hasn't submitted any alleles to the CGC.