Laboratory Information

NameKAE View on WormBase
Allele designationsea
HeadMatt Kaeberlein
InstitutionUniversity of Washington, Seattle, WA
Address 1959 NE Pacific St
HSB Room D512
Box 357470
Seattle 98195
United States
Website www.kaeberleinlab.org
Gene classes tald  impk 

Strains contributed by this laboratory

Strain Genotype Species Description
KAE10 seaSi40 I; unc-119(ed3) III. C. elegans seaSi40 [(pCFJ448) (eft-3p::fmo-2 + H2B::GFP) + Cbr-unc-119(+)] I. Higher level of FMO-2 over-expression compared to KAE9. Improved healthspan, stress resistance and longevity. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8.
KAE112 seaIs201. C. elegans seaIs201 [myo-3p::human tau (0N4R;V337M)::unc-54 3'UTR + vha-6p::mCherry::unc-54 3'UTR]. Reduced crawling speed, reduced brood size, shortened lifespan, slow development, early paralysis. Human tau transgene is expressed in body wall muscles, producing strong phenotypes suitable for screening and is sensitive to knockdown by feeding RNAi. Generated in N2 background.
KAE12 seaSi182 II; unc-119(ed3) III. C. elegans seaSi182 [(pCFJ150) (vha-6p::fmo-2 + H2B::GFP) + Cbr-unc-119(+)] II. Over-expression of FMO-2 in the intestine. Long-lived. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8.
KAE28 unc-119(ed3) III; seaEx13. C. elegans seaEx13 [fmo-2p::GFP + unc-119(+)]. Pick non-Unc to maintain. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8.
KAE9 seaSi39 I; unc-119(ed3) III. C. elegans seaSi39 [(pCFJ448) (eft-3p::fmo-2 + H2B::GFP) + Cbr-unc-119(+)] I. Lower level of FMO-2 over-expression compared to KAE10. Improved healthspan, stress resistance and longevity. Reference: Leiser SF, et al. Science 350.6266 (2015): 1375-8.
This laboratory hasn't submitted any alleles to the CGC.