Strain Information

Name HP17   View On Wormbase
Species C. elegans
Genotypesos-1(pd10) V.
Descriptionsos-1 gain-of-function allele originally isolated as a suppressor of sem-5(n1619) lethality. pd10 causes a E99K substitution within the N-terminal histone fold domain of SOS-1. Single mutants appear wild-type.
Made byNeil Hopper
Laboratory UP
Reference Wooller, A., & Hopper, N. (2004). A SCREEN FOR SUPPRESSORS OF SEM-5 LETHALITY IDENTIFIES TWO GAIN OF FUNCTION SOS-1 ALLELES presented in European Worm Meeting. Anyone using this allele may cite Neil Hopper as a personal communication based on this meeting abstract. (Neil has left academia) The allele is also used in Pu et al (2017). Genetics 205, 1247-1260.
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