Strain Information

Name HMZ245   View On Wormbase
Species C. elegans
Genotypeccar-1(sda11) IV.
DescriptionSuperficially wild-type except for a slightly shorter body length in adults. Crispr/Cas9 was used to create a 13 bp deletion in exon7 of ccar-1a; breakpoints: CTGATTCGGGAG/sda11/ATCGGAAGTTTC. sda11 is an isoform-specific deletion allele. It only affects the function of CCAR-1A and CCAR-1D, but not CCAR-1B and C. In addition, because CCAR-1D is not expressed in embryos,this allele can be used to specifically inactivate CCAR-1A (the full-length isoform that is the most similar to human CCAR1) during embryogenesis. Reference: Fu R, et al. J Cell Sci. 2018 May 10.
Made byRong Fu
Laboratory 5151
Reference Fu, R., Zhu, Y., Jiang, X., Li, Y., Zhu, M., Dong, M., Huang, Z., Wang, C., Labouesse, M. and Zhang, H. (2018). CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/Perlecan alternative splicing in the C. elegans epidermis. J Cell Sci.
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