Strain Information
| Name | HMZ245 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | ccar-1(sda11) IV. |
| Description | Superficially wild-type except for a slightly shorter body length in adults. Crispr/Cas9 was used to create a 13 bp deletion in exon7 of ccar-1a; breakpoints: CTGATTCGGGAG/sda11/ATCGGAAGTTTC. sda11 is an isoform-specific deletion allele. It only affects the function of CCAR-1A and CCAR-1D, but not CCAR-1B and C. In addition, because CCAR-1D is not expressed in embryos,this allele can be used to specifically inactivate CCAR-1A (the full-length isoform that is the most similar to human CCAR1) during embryogenesis. Reference: Fu R, et al. J Cell Sci. 2018 May 10. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x4 |
| Made by | Rong Fu |
| Laboratory | 5151 |
| Reference | Fu, R., Zhu, Y., Jiang, X., Li, Y., Zhu, M., Dong, M., Huang, Z., Wang, C., Labouesse, M. and Zhang, H. (2018). CCAR-1 affects hemidesmosome biogenesis by regulating unc-52/Perlecan alternative splicing in the C. elegans epidermis. J Cell Sci. |
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