Strain Information

Name HA3971   View On Wormbase
Species C. elegans
Genotypetdp-1(tgx286[hTARDBP]) I.
DescriptionNo obvious phenotype. C. elegans tdp-1 coding sequences were completely removed and replaced with sequences encoding human TDP43 optimized for expression in C. elegans. Three synthetic introns are introduced into the humanized locus. Reference: Lins J, et al. Generation of a C. elegans tdp-1 null allele and humanized TARDBP containing human disease-variants. MicroPubl Biol. 2023 Jun 6;2023:10.17912/micropub.biology.000693. doi: 10.17912/micropub.biology.000693. PMID: 37351305.
MutagenNo mutagen
Made byInVivo Biosystems/Nemametrix and Hart lab
Laboratory HA
Reference 10.17912/micropub.biology.000693
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