Strain Information

Name HA3299   View On Wormbase
Species C. elegans
Genotypesod-1(rt451[sod-1G85R]) II.
DescriptionSuperficially wild-type with increased sensitivity to paraquat in multiple assays. Can be maintained 15-25C. rt451 is CRISPR/Cas9 engineered G85R missense mutation in endogenous sod-1 locus mimicking human ALS SOD1 model. Reference: Baskoylu SN, et al. PLoS Genet. 2018;14(10):e1007682.
MutagenCrispr/Cas9
Outcrossedx4
Made bySaba Baskoylu
Laboratory HA
Reference Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration. PLoS Genet. 2018;14(10):e1007682. Published 2018 Oct 8. doi:10.1371/journal.pgen.1007682
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