Strain Information
Name | HA2987 View On Wormbase |
---|---|
Species | C. elegans |
Genotype | sod-1(rt449[G85RC]) II. |
Description | sod-1(rt449[G85RC]) was created by CRISPR editing of the cognate glycine codon in C. elegans sod-1 to create a disease model for human mutation G93A. This strain also contains additional silent edits, and was back-crossed to remove the pha-1 allele used in strain construction. Under normal culture conditions HA2987 animals are superficially wild-type; after stress latent defects are observed. Reference: Baskoylu S, et al. bioRxiv 799932; doi: https://doi.org/10.1101/799932 |
Mutagen | No mutagen |
Outcrossed | x4 |
Made by | Saba Baskoylu |
Laboratory | HA |
Reference | doi: 10.1371/journal.pgen.1007682 Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration Baskoylu SN et.al |
Sign in
or
register an account if you want to order this strain.