Strain Information
| Name | HA2986 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | sod-1(rt448[sod-1WT C]) II. |
| Description | Superficially wild-type at 25C. Can be maintained 15-25C. rt448 is wild-type control strain for HA3299 containing all the silent codon changes needed for CRISPR/Cas9 genome editing. Reference: Baskoylu SN, et al. PLoS Genet. 2018;14(10):e1007682. NOTE: A micropublication on these strains (PMID: 33474528) incorrectly described sod-1(rt448) as the G85R mutant version and sod-1(rt449) as the control. Additionally, the strains list in the paper also incorrectly describes rt449 as sod-1 [G85RC]. The correct descriptions are that rt448 is the wild-type control, rt449 is the sod-1 [G93AC] mutant version, and rt451 is the sod-1 [G85RC] mutant version.] |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x4 |
| Made by | Saba Baskoylu |
| Laboratory | HA |
| Reference | Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration. PLoS Genet. 2018;14(10):e1007682. Published 2018 Oct 8. doi:10.1371/journal.pgen.1007682 |
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