Strain Information
| Name | GA631 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | lin-15B&lin-15A(n765) X; wuIs177. |
| Description | wuIs177 [ftn-1p::GFP + lin-15(+)]. GFP expression in the intestine. ftn-1p::GFP transgene shows moderate basal expression under standard culture conditions in an otherwise wild-type background, but is strongly induced by reduced insulin/IGF-1 signalling, reduced HIF signalling, and increased free iron levels. References: Ackerman D & Gems D. PLoS Genet. 2012;8(3):e1002498. Valentini S, et al. Mech Ageing Dev. 2012 May;133(5):282-90. |
| Mutagen | No mutagen |
| Outcrossed | x6 |
| Made by | Daniel Ackerman |
| Laboratory | GA |
| Reference | D. Ackerman, D. Gems. 'Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in C. elegans.' PLoS Genetics (2012) 8: e1002498; S. Valentini, F. Cabreiro, D. Ackerman, M. Alam, C. Kay, D. Gems. 'Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.' Mechanisms of Ageing and Development (2012) 133: 282-290. |
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