Strain Information

Name GA631   View On Wormbase
Species C. elegans
Genotypelin-15B&lin-15A(n765) X; wuIs177.
DescriptionwuIs177 [ftn-1p::GFP + lin-15(+)]. GFP expression in the intestine. ftn-1p::GFP transgene shows moderate basal expression under standard culture conditions in an otherwise wild-type background, but is strongly induced by reduced insulin/IGF-1 signalling, reduced HIF signalling, and increased free iron levels. References: Ackerman D & Gems D. PLoS Genet. 2012;8(3):e1002498. Valentini S, et al. Mech Ageing Dev. 2012 May;133(5):282-90.
MutagenNo mutagen
Made byDaniel Ackerman
Laboratory GA
Reference D. Ackerman, D. Gems. 'Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in C. elegans.' PLoS Genetics (2012) 8: e1002498; S. Valentini, F. Cabreiro, D. Ackerman, M. Alam, C. Kay, D. Gems. 'Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans.' Mechanisms of Ageing and Development (2012) 133: 282-290.
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