Strain Information
| Name | DPB2316 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | mir-43(sjm3) II; ebax-1(tm2321) IV. |
| Description | Homozygotes lack obvious gross phenotypes, though some miRNAs are elevated due to loss-of-function mutation in ebax-1. mir-43(sjm3) has positions 9-23 of miR-43 substituted for the 3' region of miR-82. This strain is also homozygous for a G>T point substitution at position 8 of miR-42, and furthermore has 22bp of sequence deleted between mir-42* and mir-42. Generated by mating parental strain CZ9907 hermaphrodites to mir-43(sjm3) males. Reference: Stubna MW, et al. bioRxiv doi: 10.1101/2024.06.28/601170. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x1 |
| Made by | Michael Stubna |
| Laboratory | DPB |
| Reference | Stubna MW, Shukla A, Bartel DP. Widespread destabilization of C. elegans microRNAs by the E3 ubiquitin ligase EBAX-1. bioRxiv doi: 10.1101/2024.06.28/601170 |
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