Strain Information
| Name | DCR5765 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | atg-4.2(ola316) IV. |
| Description | Dominant negative allele of autophagy protease atg-4.2. Animals appear slightly dumpy. In neurons, autophagic vacuoles accumulate abnormally in the soma. Reference: Hill SE, et al. Dev Cell. 2019 Mar 8. pii: S1534-5807(19)30104-2. |
| Mutagen | EMS |
| Outcrossed | x3 |
| Made by | Sarah Hill |
| Laboratory | DCR |
| Reference | Hill, SE, Kauffman, K, Krout, M, Richmond JE, Melia, T, Colón-Ramos, DA (2019). “Maturation and Clearance of Autophagosomes in Neurons Depends on a Specific Cysteine Protease Isoform, ATG-4.2.” Developmental Cell, https://doi.org/10.1016/j.devcel.2019.02.013. |
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