Strain Information
| Name | BOX165 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | erm-1(mib10[erm-1[T544A]]) I. |
| Description | Homozygous viable. Modification of endogenous erm-1 locus mimics non-phosphorylated ERM-1(T544). Variant affects ERM-1 localization and dynamics. Reduced brood size, increased embryonic and larval lethality. Reference: Ramalho JJ, et al. Development. 2020 Jul 22;147(14):dev188011. PMID: 32586975 |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x0 |
| Made by | Joao J. Ramalho |
| Laboratory | BOX |
| Reference | Ramalho et al., 2020. C-terminal phosphorylation modulates ERM-1 localization and dynamics to control cortical actin organization and support lumen formation during Caenorhabditis elegans development. Development 147, dev188011. doi:10.1242/dev.188011 |
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