Strain Information

Name BB239   View On Wormbase
Species C. elegans
Genotypeadr-1(uu49) I; adr-2(uu28) III.
DescriptionChemotaxis deficient. Transgenes are silenced in this background. Reference: Reich DP, et al. Genes Dev. 2018 Feb 1;32(3-4):271-282. NOTE: In the referenced publication, irregularities were noted in the adr-1(gv6);adr-2(gv42) null strain, which were ascribed to background mutationsint hat strain. This strain -- adr-1(uu49);adr-2(uu28) -- was generated Crispr/Cas9 targeted mutation and phenotypes are more consistent with another null strain, adr-1(tm668);adr-2(ok735).
Made byDaniel Reich
Laboratory BB
Reference Reich, DP, Tyc, KM, and Bass, BL (2018). C. elegans ADARs antagonize silencing of cellular dsRNAs by the antiviral RNAi pathway. Genes Dev 32, 271-282.
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