Strain Information
| Name | TLG697 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | texIs127 X. |
| Description | texIs127 [spp-9p::GFP] X. GFP expression in intestine and six aphid neurons, including AWB and AWC, serves as a reporter for DBL-1 signaling (fluorescence is high when DBL-1 signaling is low, and low when DBL-1 signaling is high). This reporter is also responsive to starvation, select bacterial pathogens, and loss of other innate immune signaling pathways, including tir-1 and pmk-1 (but not sek-1 or mek-1). texIs127 created by X-ray integration of extrachromosomal array wkEx52 into N2 animals using UV/TMP. Out-crossed five times to the N2. References: Lakdawala ML, et al. Mol Biol Cell. 2019 Dec 15;30(26):3151-3160. doi: 10.1091/mbc.E19-09-0500. PMID: 31693440. Roberts AF, et al. 2010 Jun 7:10:61. doi: 10.1186/1471-213X-10-61. PMID: 20529267. |
| Mutagen | UV/TMP |
| Outcrossed | x5 |
| Made by | Bhoomi Madhu |
| Laboratory | TLG |
| Reference | Lakdawala, M.L., Madhu, B., Faure, L., Vora, M., Padgett, R.W., and Gumienny, T.L. (2019) Genetic interactions between the DBL-1/BMP-like pathway and dpy body size-associated genes in Caenorhabditis elegans. Molecular Biology of the Cell 30(26):3151-3160. DOI: 10.1091/mbc.E19-09-0500. Madhu, B., Lakdawala, M.L., Issac, N.G., and Gumienny, T.L. (2020) Caenorhabditis elegans saposin-like spp-9 is involved in specific innate immune responses. Genes & Immunity 1-10. DOI: https://doi.org/10.1038/s41435-020-0108-6. |
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