Strain Information
| Name | SZ454 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | mog-5(az192) II. |
| Description | Directed mutagenesis of mog-5 removed 17 amino acids and inserted 9 different amino acids at the site of structural interface with SACY-1, promoting upstream alternative 3'ss usage in somatic cells in a pattern similar to sacy-1 mutants and similar to a switch that occurs in the germline. Changes alternative 3' splice site usage to upstream 3' splice site in somatic cells for 76 different alternative splicing events. No obvious morphological phenotypes. Reference: Osterhoudt K, et al. RNA. 2024 Jan 24:rna.079888.123. doi: 10.1261/rna.079888.123. PMID: 38282418. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x1 |
| Made by | Kenneth Osterhoudt |
| Laboratory | SZ |
| Reference | Spliceosomal helicases DDX41/SACY-1 and PRP22/MOG-5 both contribute to proofreading against proximal 3’ splice site usage Kenneth Osterhoudt, Orazio R. Bagno, Sol Katzman, and Alan M Zahler RNA Published in Advance January 24, 2024, doi:10.1261/rna.079888.123 |
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