Strain Information
| Name | SZ370 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | snu-66(az160) V. |
| Description | SNU-66 H765G substitution. No obvious morphological or growth phenotypes were observed. az160 mutation disrupts SNU-66(H765)/SNRP-27(M141) interaction, affecting alternative 5' splice site usage. Worm SNU-66(H765) and SNRP-27(M141) are homologous to human preB spliceosome components snu66(H734) and snrnp27(M141), respectively. Reference: Sarka K, et al. 2024. In submission. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x1 |
| Made by | Kenna Sarka |
| Laboratory | SZ |
| Reference | Sarka, K., Katzman, S. and Zahler, A.M. 2024. A Role for SNU66 in Maintaining 5’ Splice Site Identity During Spliceosome Assembly. Submitted to RNA Journal. |
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