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|Species|| C. elegans |
|Description||snrp-27(az56) is a M141T missense allele with semi-dominant suppression of e936. No phenotype on its own. az56 is a CRISPR-induced mutation mimicking a known suppressor of unc-73(e936). This allele activates many dozens of alternative 5' splice sites in an RNA-seq experiment. snrp-27 is a component of the tri-snRNP and pre-B spliceosomal complexes. Reference: Zahler AM, et al. RNA. 2018 Oct;24(10):1314-1325.
doi: 10.1261/rna.066878.118. PMID: 30006499.|
|Made by||Alan Zahler|
|Reference ||Zahler et al. (2018) SNRP-27, the C. elegans homolog of the tri-snRNP 27K protein, has a role in 5′ splice site positioning in the spliceosome. RNA 24:1314–1325. http://www.rnajournal.org/cgi/doi/10.1261/rna. 066878.118.|