Strain Information
| Name | SZ211 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | snrp-27(az56) I. |
| Description | snrp-27(az56) is a M141T missense allele with semi-dominant suppression of e936. No phenotype on its own. az56 is a CRISPR-induced mutation mimicking a known suppressor of unc-73(e936). This allele activates many dozens of alternative 5' splice sites in an RNA-seq experiment. snrp-27 is a component of the tri-snRNP and pre-B spliceosomal complexes. Reference: Zahler AM, et al. RNA. 2018 Oct;24(10):1314-1325. doi: 10.1261/rna.066878.118. PMID: 30006499. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x1 |
| Made by | Alan Zahler |
| Laboratory | SZ |
| Reference | Zahler et al. (2018) SNRP-27, the C. elegans homolog of the tri-snRNP 27K protein, has a role in 5′ splice site positioning in the spliceosome. RNA 24:1314–1325. http://www.rnajournal.org/cgi/doi/10.1261/rna. 066878.118. |
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