Strain Information
| Name | QV211 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | wdr-23(tm1817) I; zjEx53. |
| Description | zjEx53 [gst-4p::tdTomato::unc-54 3'UTR]. Pick bright tdTomato to maintain the array. Worms with zjEx53 express tdTomato strongly throughout the body. Small and slow-growing with strong constitutive activation of SKN-1 and downstream detoxification genes. References: Choe KP, et al. Mol Cell Biol. 2009 May;29(10):2704-15. doi: 10.1128/MCB.01811-08. PMID: 19273594. Tang L, et al. Mech Ageing Dev. 2015 Jul;149:88-98. doi: 10.1016/j.mad.2015.06.001. PMID: 26056713. |
| Mutagen | No mutagen |
| Outcrossed | x4 |
| Made by | Lanlan Tang |
| Laboratory | QV |
| Reference | The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans. Choe KP, Przybysz AJ, Strange K. Mol Cell Biol. 2009 May;29(10):2704-15. doi: 10.1128/MCB.01811-08 Characterization of skn-1/wdr-23 phenotypes in Caenorhabditis elegans; pleiotrophy, aging, glutathione, and interactions with other longevity pathways. Tang L, Choe KP. Mech Ageing Dev. 2015 Jul;149:88-98. doi: 10.1016/j.mad.2015.06.001. Epub 2015 Jun 6. PMID: 26056713 |
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