Strain Information

Name QR189   View On Wormbase
Species C. elegans
GenotypevhIs12 tbc-2(tm2241) II; unc-119(ed3) III.
DescriptionvhIs12 [vha-6p::GFP::tbc-2 + Cbr-unc-119(+)] II.  vhIs12 is inserted to the left of tbc-2(m2241) in LG II. GFP::TBC-2 rescues the large endosome phenotype in the intestine of tbc-2(tm2241) animals. Outside the intestine, tbc-2(tm2241) animals have large yolk platelets in the oocytes and early embryos that are not rescued.
Made byLaetitia Chotard
Laboratory QR
Reference Chotard, L., Mishra, A. K., Sylvain, M. A., Tuck, S., Lambright, D. G., & Rocheleau, C. E. (2010). TBC-2 regulates RAB-5/RAB-7-mediated endosomal trafficking in Caenorhabditis elegans. Mol Biol Cell, 21, 2285-96. doi:10.1091/mbc.E09-11-0947
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