Strain Information
Name | OG1157 View On Wormbase |
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Species | C. elegans |
Genotype | ogt-1(dr84[ogt-1::GFP] dr94[delta-TPR domain]) III. |
Description | TPR domain deleted in the endogenous ogt-1 locus tagged with C-terminal GFP. The TPR domain deletion spans 128 aa - 583 aa. OGT-1(delta-TPR)::GFP is expressed ubiquitously in somatic tissues with a nuclear localization. The TPR domain deletion ablates the O-GlcNAcylation activity of OGT-1 as measured by the RL2 O-GlcNAc antibody. Sanger sequence confirmed. Reference: Urso SJ, et al. (2020). The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress. bioRxiv, 2020.2005.2001.072033. |
Mutagen | Crispr/Cas9 |
Outcrossed | x0 |
Made by | Sarel Urso |
Laboratory | OG |
Reference | Urso, S.J., Comly, M., Hanover, J.A., and Lamitina, T. (2020). The O-GlcNAc transferase OGT is a conserved and essential regulator of the cellular and organismal response to hypertonic stress. bioRxiv, 2020.2005.2001.072033. |
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