Strain Information
| Name | MD5004 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | drp-1(dx230[drp-1::mNeonGreen]) IV. |
| Description | mNeonGreen tag inserted into the variable region of endogenous drp-1 locus (internal tag). N- and C-terminal fusions of DRP-1 cause a block in mitochondrial fission (acting as dominant-negatives), whereas internally-tagged DRP-1 protein has close to wild-type activity. Generated in N2 background. Reference: Lambie EJ & Conradt B. MicroPubl Biol. 2025 May 8;2025:10.17912/micropub.biology.001588. PMID: 40415901. |
| Mutagen | CRISPR-Cas9 |
| Outcrossed | x3 |
| Made by | Eric Lambie |
| Laboratory | MD |
| Reference | Lambie EJ & Conradt B. 2025. Insertion of mNeonGreen into the variable domain of DRP-1 permits visualization of functional endogenous protein. MicroPubl Biol. 2025 May 8;2025:10.17912/micropub.biology.001588. PMID: 40415901 |
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