Strain Information
| Name | MCJ211 View On Wormbase |
|---|---|
| Species | C elegans |
| Genotype | mir-35(cdb2 cdb95) II. |
| Description | cdb2 cdb95 is a mutation to the seed region of the mature mir-35, reversing the seed sequence and altering the pri-miRNA structure. This mutant mir-35 has little impact on embryonic mir-35 abundance but strongly inhibits its decay at embryo to L1. Superficially wild-type. Reference: Donnelly BF, et al. (2022). The developmentally-timed decay of an essential microRNA family is seed sequence-dependent. BioRxiv 2021.11.19.469346. |
| Mutagen | Crispr/Cas9 |
| Outcrossed | x0 |
| Made by | Bridget Donnelly |
| Laboratory | MCJ |
| Reference | Donnelly, B.F., Yang, B., Grimme, A.L., Vieux, K.-F., Liu, C.-Y., Zhou, L., and McJunkin, K. (2022). The developmentally-timed decay of an essential microRNA family is seed sequence-dependent. BioRxiv 2021.11.19.469346. |
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