Strain Information
| Name | MC942 View On Wormbase |
|---|---|
| Species | C elegans |
| Genotype | larp-1(q783) ncl-1(gc53) III; fem-3(q20) IV. |
| Description | Maintain at 15C. Temperature-sensitive sterile: fem-3 XX germline makes oocytes and excess sperm at 15C, but only sperm at 25C. Triple mutants are resistant to hypoxia as adults but not as larvae. Triple mutant control strain; mutations in ncl-1 and larp-1 do not suppress hypoxia resistance of fem-3(q20). Reference: Hemphill C, et al. PLOS Genet. 2022 May 27;18(5):e1009672. PMID: 35622856. |
| Mutagen | No mutagen |
| Outcrossed | x6+ |
| Made by | Omar Italy |
| Laboratory | MVG |
| Reference | Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants Hemphill C, Pylarinou-Sinclair E, Itani O, Scott B, Crowder CM, et al. (2022) Daf-16 mediated repression of cytosolic ribosomal protein genes facilitates a hypoxia sensitive to hypoxia resistant transformation in long-lived germline mutants. PLOS Genetics 18(5): e1009672. https://doi.org/10.1371/journal.pgen.1009672 |
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