Strain Information
| Name | LSD2104 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | xchIs15. |
| Description | xchIs15[hsp-16.2p::ssSel1::FLAG::superfolderGFP::spacer::humanAmylo idBeta1-42::let-858 3’UTR + rol-6(su1006)]. Maintain at 15C: Prone to transgene suppression at higher temperatures. Rollers. Upon heat shock, human amyloid beta is expressed and secreted into the extracellular space. Aggregates are found in the extracellular space after 16 hours. Generated in N2 background. Reference: Jongsma E, et al. eLife. 2023 Sep 20;12:e83465. doi: 10.7554/eLife.83465. PMID: 37728486. |
| Mutagen | No mutagen |
| Outcrossed | x4 |
| Made by | Eline Jongsma |
| Laboratory | LSD |
| Reference | Elisabeth Jongsma Anita Goyala José Maria Mateos Collin Yvès Ewald (2023) Removal of extracellular human amyloid beta aggregates by extracellular proteases in C. elegans eLife 12:e83465. https://doi.org/10.7554/eLife.83465 |
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