Strain Information

Name KRA235   View On Wormbase
Species C. elegans
Genotypepha-1(e2123) III; kasEx80.
DescriptionkasEx80 [oig-1p::tagRFP::unc-54 3'UTR + pha-1(+)]. Maintain at 25C to maintain array. RFP driven by minimal oig-1 promoter for expression in VD-type GABAergic motor neurons. This construct uses the minimal length of promoter containing overlapping LIN-39 and UNC-30 ChIp-seq peaks (deletion of the single LIN-39 binding site within it compromised GABAergic motor neuron expression). Whereas other available oig-1 constructs are expressed ectopically in cholinergic motor neurons in unc-3 mutants, expression of this construct remains exclusively in GABAergic motor neurons. Reference: Feng W, et al. Elife. 2020 Jan 3;9. pii: e50065. doi: 10.7554/eLife.50065.
MutagenNo mutagen
Made byMelanie Le Gouez
Laboratory KRA
Reference Feng, Weidong, et al. "A terminal selector prevents a Hox transcriptional switch to safeguard motor neuron identity throughout life." bioRxiv (2019): 643320.
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