Strain Information
| Name | KG744 View On Wormbase |
|---|---|
| Species | C. elegans |
| Genotype | pde-4(ce268) II. |
| Description | Hyperactive locomotion and hypersensitive to stimuli such as plate dropping. Restores wild type levels of locomotion to paralyzed ric-8(md303) mutants. Most, but not all adults, appear significantly Egl-c. Some mature adults are thinner than normal. Aldicarb sensitivity, growth rate, pumping, length, and distribution on food are all similar to wild type. The ce268 mutation is a D448N change relative to PDE-4D isoform. It disrupts the catalytic domain by changing one of the four active site residues that together chelate an active site zinc atom. Inheritance is semi-dominant due to dominant negative side effects. |
| Mutagen | EMS |
| Outcrossed | x5 |
| Made by | Ken Miller |
| Laboratory | KG |
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