Strain Information
| Name | JTL720 View On Wormbase |
|---|---|
| Species | C elegans |
| Genotype | haps-1(ljt1) I. |
| Description | CRISPR-engineered KO strain of haps-1 made by knock-in of tandem stop codons to the first exon of endogenous haps-1 locus. haps-1(C48B6.3) is the C. elegans ortholog of human HAPSTR1. haps-1(ljt1) is superficially wild-type when cultured at 20C, but is hypersensitive to paraquat (redox stress), MLN4924 (neddylation inhibition), and camptothecin (genotoxic stress). Reference: Amici DR, et al. Proc Natl Acad Sci U S A. 2022 Jul 5;119(27):e2111262119. doi: 10.1073/pnas.2111262119. PMID: 35776542. |
| Mutagen | No mutagen |
| Outcrossed | x6 |
| Made by | Jian Li |
| Laboratory | JTL |
| Reference | Amici DR et al. (2022) Proc Natl Acad Sci U S A "C16orf72/HAPSTR1 is a molecular rheostat in an integrated network of stress response pathways." |
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