Strain Information

Name JPS845   View On Wormbase
Species C. elegans
GenotypevxIs823 II; vxIs824; vxIs591.
DescriptionvxIs823 [rab-3p::APP::mCherry::unc-54 3'UTR] II. vxIs824 [rab-3p::ND18ApoE4::unc-54 3'UTR + myo-2p::mCherry::unc-54 3'UTR]. vxIs591 [tph-1p::GFP::unc-54 3'UTR]. Integrated transgenes driving expression of human APOE4 and human APP throughout the nervous system; induces age-related neurodegeneration of HSNs and bag-of-worms in >60% of D3 adult worms. GFP expression in all serotonergic neurons. Reference: Sae-Lee et al. G3 (Bethesda) 2020 Aug 5;10(8):2851-2861. PMID: 32580938
MutagenNo mutagen
Made bySusan Rozmiarek
Laboratory JPS
Reference Sae-Lee et al. (2020) APP-induced patterned neurodegeneration is exacerbated by APOE4 in Caenorhabditis elegans. G3 10(8): 2851-2861. doi:10.1534/g3.120.401486
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